lithium, Tegretol, or Depakote?
An interaction between lithium and lamotrigine has not been reported. Carbamazepine induced enzymes that facilitate the metabolism of lamotrigine. Because of that, blood levels of lamotrigine are somewhat lower in people taking carbamazepine than in those not taking carbamazepine. Valproate has the ability to double plasma levels of lamotrigine. Because of that, when lamotrigine is started in people taking valproate, the initial dose should be approximately one-half as much as is usually initially prescribed.
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