levels will be maintained at near-maximum with once daily dosing. 4.3: Is it necessary to cycle creatine?
creatine is administered, natural production of creatine is drastically reduced. Creatine transporters also downregulate as creatine stores are maximized. For this reason, some recommend cyclic use of creatine to allow natural production to return to normal. However, there is no evidence that this is necessary. Because supplemental creatine leads to creatine levels much higher than would be produced naturally, there is no reason to try to maintain natural creatine production while trying to take creatine it will not alter the effectiveness of the creatine. If creatine is taken consistently, muscle creatine levels are maintained at their maximal level, and do not decrease. Some believe that if creatine is taken for too long it could lead to permanent shutdown or a decrease of natural creatine production, but studies have found that natural production is restored very quickly after supplementation discontinues.
