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I’ve heard that dicalcium phosphate is unsafe, yet many manufacturers use it as an excipient in their products. What’s your take?

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I’ve heard that dicalcium phosphate is unsafe, yet many manufacturers use it as an excipient in their products. What’s your take?

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There is absolutely no evidence that dicalcium phosphate is harmful. This notion got some publicity a number of years ago, largely due to a mail order company that put out brochures claiming calcium phosphate was bad. Their arguments were very unscientific and speculative at best. The few studies they cited did not support this contention at all. It was mainly a marketing ploy to make their products look superior because they did not use calcium phosphate. This is classic example of a spurious argument that takes on a life of its own through repetition.

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