Is wound bed preparation a critical part in advanced therapeutic products?
Certainly, it is highly unlikely that a wound will heal when covered by necrotic tissue. Indeed, there is evidence that more aggressive surgical debridement of diabetic ulcers leads to improved results with the use of a topically applied growth factor (PDGF). It is generally accepted that pressure ulcers need to be extensively debrided and their undermined tissue removed. The removal of the lipodermatosclerotic tissue in venous ulcers is beneficial.
