Is weight gain a potential side effect for Depo-Provera users?
Some, but not all studies, have demonstrated weight increase associated with the use of Depo-Provera. It is believed that this weight gain may in fact be due to increased food intake secondary to appetite stimulation rather than due to Depo-Provera itself. Weight gain should be discussed with your woman prior to prescribing Depo-Provera and good eating habits should be emphasized. Some women may report a weight gain of 2.5 Kg in the first year of use up to 6.3 Kg after the fourth year of use.