Is use of Interferon a contraindication to vaccination?
Yes, using Interferon is a contraindication for smallpox vaccination because it suppresses the immune system. Concurrent administration of exogenous interferon products may inhibit viral replication and thus reduce antibody response to the vaccine. The same rule shou ld be applied to Interferon as is valid for the use of high-dose steroids, individuals would need to be completely off the drug for three months before vaccination.