Is transplantation to be used to REPLACE already lost retinal cells or to rescue cells before they die?
The answer based on existing experimental DATA is that both purposes can be served by transplantation. Of course, different conditions, and even different stages of the same condition will require different strategies. In the case of neural retinal transplantation, the cells are used to REPLACE lost photoreceptor cells. In the case or RPE transplantation, the cells used for the anatomical or functional replacement of lost or damaged RPE cells. This replacement may in turn rescue remaining photoreceptor cells. In both cases, a functioning inner retina is a prerequisite. Diseases such as retinitis pigmentosa and AMD are prime candidates for transplantation treatment. The requirements for successful neural transplantation in RP are dependent on the existence of a functioning inner retina and to the presence of some remaining plasticity in the host retina. It is to be noted in this regard, that electrical stimulation of the retina in RP patients has shown that indeed the inner retina circu
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