Is there any way to convert downstream GO terms to a GO slim term?
There is a script, map2slim.pl, that does essentially this. It uses the GO MySQL database and Perl API, so you should familiarize yourself with those. The script is in the directory http://www.fruitfly.org/developers/src/go-dev/apps/query-utils/ Database and API documentation are available: • http://www.godatabase.org/dev/database/ • http://www.godatabase.org/dev/develop.html • http://www.fruitfly.org/cgi-bin/wiki/view.pl/GoWeb/GoAPI Web-based implementations of map2slim are also available; GO Term Mapper is a tool developed at Princeton University which can be used to map terms to their corresponding GO slim term for any species, while the SGD Gene Ontology Slim Mapper does the same for Saccharomyces cerevisiae data.