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Is there any risk to treatment of a multinodular goitre with radioactive iodine?

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Is there any risk to treatment of a multinodular goitre with radioactive iodine?

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Patients may experience some degree of neck discomfort and swelling in the region of the thyroid gland following radioactive iodine. Furthermore, destruction of thyroid tissue is often associated with transient worsening of the hyperthyroidism for a few weeks, and in elderly subjects with a history of heart disease, this can be a serious issue. There is some evidence that older subjects treated with radioactive iodine may have an increased risk of mortality, but not if the treatment is sufficiently effective so as to induce hypothyroidism Increased cardiovascular and cancer mortality after radioiodine treatment for hyperthyroidism. J Clin Endocrinol Metab.

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