IS THERE ANY EVIDENCE FOR THE EXISTENCE HYPERTHYROID HEPATIC STATE FOLLOWING CHRONIC ALCOHOL INTAKE?
The hepatic concentrations of thyroid hormones were studied in female Sprague-Dawley rats (N = 24) pair-fed nutritionally adequate liquid diets containing either ethanol (36% of total calories) or isocaloric carbohydrates for 21 days. Compared to controls, prolong4 alcohol consumption failed to result in significant alterations of hepatic thyroid hormone levels (T4: 14.7 ± 1.81 ng/g of Liver wet weight vs 15.0 ± 1.59; T3: 2.60 ± 0.16 ng/g of liver wet weight vs 2.66 ± 0.18). Similar results were obtained when the hepatic levels of thyroid hormones were expressed per total liver, per g of liver protein or per 100g of b d y weight. These data therefore provide no evidence for a ‘hyperthyroid hepatic state’ following chronic alcohol consumption.
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