Is there any drug-to-drug interaction?
The body metabolizes, or breaks down many drugs in the liver with a specific group of proteins known as enzymes. When Gleevec is taken at the same time as some other drugs, these enzymes may preferentially break down one drug over another which can result in higher or lower than expected levels of Gleevec and/or other drugs in the bloodstream. These effects are known as drug to drug interactions. In particular, analgesics (e.g., acetaminophen, fentanyl, and alfentanil), blood thinners (especially warfarin), antifungals (e.g., ketoconazole, itraconazole, and voriconazole), antivirals (e.g., atazanavir, indinavir, nelfinavir, ritonavir, and saquinavir), antibiotics (e.g., clarithromycin, telithromycin), antidepressants (e.g., nefazodone), immunosuppressants (e.g., cyclosporine, sirolimus, and tacrolimus), vasoconstrictors (e.g., diergotamine and ergotamine), antipsychotics (e.g., pimozide), antiarrhythmics (e.g., quinidine), anticonvulsants (e.g., triazolo-benzodiazepines), dihydropyridi
