Is there any brain region particularly affected by neuroinflammation?
Yes. Our study showed the cerebellum exhibited the most prominent neuroglial responses. The marked neuroglial activity in the cerebellum is consistent with previous observations that the cerebellum is a major focus of pathological abnormalities in microscopic and neuroimaging studies of patients with autism. Based on our observations, selective processes of neuronal degeneration and neuroglial activation appear to occur predominantly in the Purkinje cell layer (PCL) and granular [needs to be defined] cell layer (GCL) areas of the cerebellum in autistic subjects. These findings that are consistent with an active and ongoing postnatal process of neurodegeneration and neuroinflammation. Our observations suggest that the pathological changes observed in the cerebellum in autistic patients do not occur exclusively during prenatal development, but appear to involve an ongoing chronic neuroinflammatory process that involves both microglia and astroglia. Furthermore, this process continues bey
