Is there any animal model for amyotrophic lateral sclerosis?
A transgenic mouse model possesses mutations in the gene encoding the cytosolic form of the enzyme copper-zinc superoxide dismutase (Nature 1993; 362: 59). kou Gehrig, the American baseball player, died from amyotrophic lateral sclerosis 50 years ago. Charcot gave a detailed clinical and pathological description of amyotrophic lateral sclerosis in 1865. Professor Stephen Hawking, the Cambridge theoretical physicist, is the most famous sufferer of motor neuron disease. It claimed the lives of the actor David Niven, the football manager Don Revie and the wartime pilot Sir Leonard Cheshire, VC.
