Is there an interaction between Lamictal and Depakote?
• A: According to the literature, there is a moderate interaction between Lamictal (lamotrigine) and Depakote (divalproex); however, these medications are often prescribed together. Typically the dose of Depakote is reduced when Lamictal is added to the treatment regimen because the two drugs together can cause increased side effects such as drowsiness and tiredness. A doctor will typically closely monitor the levels of the medication in your system by doing a blood test periodically and if necessary they will adjust the dose of either of the medications as appropriate. The key is to make sure you are under the close supervision of a doctor when taking these medications together, and be sure to report any unusual or worsening side effects to your doctor immediately.
