Is there a typical age at which bradykinin-mediated angioedema first occurs?
Signs and symptoms of hereditary angioedema (HAE), including, for example, abdominal pain, can occur in early childhood. In many cases, symptoms first manifest during puberty, a period during which the frequency and severity of attacks often increases. Despite the early age of onset, the diagnosis of HAE is typically made much later because the disease is often not immediately recognised. If, however, symptoms first appear after the age of 30 years and no family members suffer from similar symptoms, other forms of angioedema must also be considered.
