Is there a true requirement for follicle stimulating hormone in promoting spermatogenesis and fertility in primates?
Although the role of follicle stimulating hormone (FSH) in regulating ovarian function is well accepted, its need in regulating testicular function of the adult continues to be debated. Sertoli cells of all mammals have FSH receptors and are known to regulate differentiation and transformation of germ cells to spermatozoa. However, there appear to be species and age differences in the way in which FSH regulates spermatogenesis. An attempt has been made in the current paper to examine critically the newer data available in support of and against the concept that FSH is required to regulate spermatogenesis and fertility of the primate. As there is no evidence to indicate that testicular function in monkeys and humans is regulated differently, the information available using the monkey as the experimental surrogate model is discussed in some depth. These are correlated, wherever feasible, to the newer information emerging from clinical studies. It appears from these studies that in the pr
