Is there a resource of published methods that are optimized for particular biomarkers and biospecimens?
The NCI Best Practices focus on principles; details will be published in appendices, which are currently under development. Additionally, guidance concerning all levels and elements of best practices will be available on the NCI Office of Biorepositories and Biospecimen Research (OBBR) Web site in the future. Data on specific biomolecules as analyzed on specific platforms are difficult to find, often buried in the “materials and methods” sections of studies performed with other goals in mind. The NCI Biospecimen Research Network (BRN) is improving accessibility to existing evidence on how biospecimen variables affect molecular analyses via annual symposia and the Biospecimen Research Database (BRD). The BRD is a searchable Web-based tool developed in collaboration with the RAND Corporation to survey and curate the existing scientific literature for research data that define the precise relationships between biospecimen handling and the quality and reproducibility of data for cancer res
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