Is there a relationship between Cu metabolism and (a) neurodegenerative diseases and (b) cardiovascular diseases?
Findings in the field of molecular biology suggest an association between Cu metabolism and neurodegenerative diseases. Also, there are mechanisms that suggest a relationship between Cu intake and coronary heart disease (CHD) Neurodegenerative diseases Neurodegenerative diseases appear to be directly related to Cu metabolism. Menkes’ syndrome and Wilson’s disease are inherited disorders with a functional disturbance of two membrane-located ATP-ases for the transport of Cu ions (Bull et al, 1993; Chelly & Monaco, 1993). In Wilson’s disease Cu excretion via the bile ducts is disturbed. Consequently, Cu accumulates predominantly in the liver. In Menkes’ syndrome, on the other hand, Cu-dependent enzymes, such as cytochrome-C oxidase and lysyloxidase, are not adequately supplied with Cu. In Menkes’ syndrome, clinical and pathological features are already present at birth, implying that Cu-dependent enzymes are of importance already in the prenatal phases of CNS growth and development. Myeli
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