Is there a recommended time of day to send submissions?
A. Submissions can be transmitted at anytime via the FDA ESG. We recommend that you send large submissions via the FDA ESG after 4:30 PM EST. This should enable your submission to be received, processed and delivered to the Center overnight. Delivery and processing time is dependent upon the overall size of your submission; larger submissions will take longer to be delivered and processed. You will be sent an acknowledgement from the receiving Center with the date and time your submission arrived. The Center acknowledgement will contain the business rules used to determine the official receipt date of your submission.