Is there a dose-response relationship for Pulmicort Turbuhaler?
Several clinical dose-response studies have shown a statistically significant dose-response relationship. However, the dose-response curve is rather flat, which means that it has been hard to find statistically significant differences between doubling doses. A four times higher dose has been required for demonstrating a difference between doses (1,2) Based on results of dose-response studies different maintenance doses of Pulmicort for the treatment of asthma can be recommended. Patients with mild persistent asthma are usually well controlled on 100 µg to 400 µg Pulmicort daily, patients with moderate severe asthma on 400 µg to 800 µg daily, and patients with severe persistent asthma on 800 µg to 1600 µg daily. It should be noticed, however, that patients requiring daily doses of Pulmicort above 800 µg usually are better controlled on a combination of an inhaled corticosteroid and an inhaled long-acting ß2-agonist (3). Dose-response with Pulmicort Turbuhaler in patients not previously
