Is there a direct bus from Guelph to Kitchener?
No, there is not. The only bus option is the Greyhound. You could possibly take the train from Guelph to Kitchener and then Grand River Transit bus from the train station area to the bus terminal and then get a direct city bus from there to Conestoga College. It would be a long trip though. Check for ride sharing in your area. Sadly, car travel is the easiest and quickest way to travel between Guelph and KW.
