Is there a different class of drugs thats involved in excitatory transmission versus dis-inhibition?
Well, if you think about drugs of abuse, all drugs of abuse seem to speed the activity of dopamine cells. Now glutamate is not a drug of abuse. It’s just a neurotransmitter that speeds dopamine cells. There are not many drugs of abuse that directly activate dopamine cells; they mostly affect them indirectly.One example of one drug that does is nicotine. Nicotine activates dopamine cells directly. So different classes of drugs have either a disinhibitory or an excitatory result? So opioids cause the disinhibition. Nicotine causes a direct excitation. Things like cocaine and amphetamine, if anything, they cause an inhibition of dopamine cells, and the way they do that is by blocking the reuptake molecule that takes dopamine out of the extracellular space. And that would cause an inhibition of dopamine cells.But the key thing is that these things do the same thing at the terminal areas of the dopamine cells. So in the nucleus accumbens and the prefrontal cortex, dopamine hangs around long
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