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Is there a difference in the types of serology tests available for making a diagnosis of CAE virus infection?

April 26, 2017CAE diagnosis difference infection serology tests types virus

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Is there a difference in the types of serology tests available for making a diagnosis of CAE virus infection?

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Yes, WADDL has a validated and USDA licensed competitive Enzyme Linked Immunosorbent Assay (cELISA) for CAE virus antibodies. This test is more sensitive (ability to detect true positive animal) than the agar gel immunodiffusion (AGID) test. Values for the CAE cELISA have been set by double testing goat sera by ELISA and a very sensitive research assay, called immunoprecipitation. The positive cutoff score for the cELISA had a sensitivity of 100%, and specificity of 99.6%.

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Yes, WADDL has a validated and USDA licensed (cELISA) for CAE virus antibodies. This test is more sensitive (ability to detect true positive animal) than the agar gel immunodiffusion (AGID) test (sensitivity of 85%-90% and specificity of 100%). Values for the CAE cELISA have been set by double testing goat sera by ELISA and a very sensitive research assay, called immunoprecipitation. The positive cutoff score for the cELISA had a sensitivity of 100%, and specificity of 99.6%, which means there is a false positive rate of 4 out of every 1,000 samples tested.