Is there a connection between lindane and seizures?
The proconvulsant properties of repeated low doses of lindane were reported by Joy and colleagues and it has been since this time that lindane has been used as a kindling agent for studying seizures in rats. M.E. Gilbert published her work with rats and lindane in, Toxicology and Industrial Health, Vol. 10, No. 4, 1994, Neurotoxicology and Teratology, Vol. 17, No 2 1995. Gilbert chose lindane for her studies because of its pharmacokinetic and pharmacodynamic properites well characterized in the rat. Those who think it is okay to keep prescribing lindane need to think again!
