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Is the use of the progesterone hormones safe during pregnancy?

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Is the use of the progesterone hormones safe during pregnancy?

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The existing data suggests that progesterone treatment in the first trimester of pregnancy does not pose a teratogenic risk. Two meta-analyses failed to show increased risk in general, or specifically, for genitourinary malformations, with oral contraceptives (Obstet Gynecol 1995; 85:141-9).

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