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Is the serum FLC assay as sensitive as IFE for detecting minimal residual disease?

April 26, 2017assay detecting disease FLC ife residual sensitive serum

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Is the serum FLC assay as sensitive as IFE for detecting minimal residual disease?

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Serum FLC assays are more sensitive than IFE for detecting minimal residual disease. A large subset of patients who are in complete remission (CR) by IFE have been shown to be abnormal by serum FLC assay. It has been shown that an abnormal κ/λ ratio during IFE CR is indicative of a higher risk of early relapse.