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Is the ratio of total cholesterol (TC) to HDL cholesterol (HDL-C) useful in assessing risk?

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Is the ratio of total cholesterol (TC) to HDL cholesterol (HDL-C) useful in assessing risk?

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A total cholestererol to HDL cholesterol ratio (TC/HDL-C) greater than 5 is associated with an increased risk of heart attack. However, in those with high triglyceride levels, this ratio may not be valid. As a general rule, however, a TC to HDL-C ratio greater than 5 indicates an increased risk, while a ratio below four is associated with reduced risk.

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