Is the protocol fool-proof for non-chemists?
The protocol in the manual provides a detailed step-by step instruction for a standard scale synthesis. Some calculation is still required by the user, but once a specific protocol has been established at a facility this is hardly ever changed. We recommend a textbook on peptide chemistry for background reading. There should be someone around with a thorough understanding what the chemistry is about and what problems could arise. QC procedures are just mentioned as references without details.
