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Is the platelet serotonin transporter different in venous vs. arterial blood?

April 26, 2017Arterial blood different PLATELET Serotonin transporter venous vs

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Is the platelet serotonin transporter different in venous vs. arterial blood?

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The binding of labelled paroxetine to the serotonin transporter (SERT) of platelet membranes has been studied in both venous and mixed venous/arterial blood of the rat. In addition, we studied the inhibition of paroxetine binding to SERT by quipazine and N-methyl-quipazine (NMQ). The results indicate differences in affinity for the two test drugs, quipazine and NMQ, in venous vs. mixed venous/arterial blood. This suggests different post-translational modifications of SERT in platelets of arterial vs. venous blood.