Is the monocular trial useful in clinical practice?
Currently there are no data that strongly confirm or refute the validity of the monocular trial. Most studies examined whether IOP response in the trial eye predicts IOP response in the fellow eye and erroneously equate this to testing the validity of the trial [13]. The few studies that compared adjusted and unadjusted IOP response of the trial eye compared them to the IOP response of the fellow eye as opposed to subsequent IOP response in the trial eye after the trial. Analyzing the monocular trial using different baseline visits for both eyes introduces error from variability of IOP between visits and a possible contralateral effect. However, the use of similar baseline visits precludes the ability to adjust IOP of the fellow eye. While there is still debate regarding the validity of the monocular trial in determining medication response, it is clear that the monocular trial provides other additional benefits to bilateral simultaneous trials. Such benefits include assessment of medi
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