Is the latent period and progressive increase in seizure frequency model dependent?
Whether the progressive increase in seizure rate is common to all types and models of acquired epileptogenesis (including humans), or may simply reflect a particular animal model, also requires additional investigation. Some studies in models of TLE have not observed progressive increases in seizure rate (Gorter et al., 2001; Mazarati et al., 2002; Bragin et al., 2004), but our data strongly suggest that both continuous and prolonged seizure monitoring is required to detect the progressive increase in seizure frequency. A recent study using discontinuous monitoring on pilocarpine-treated rats (Jung et al., 2007) reported the presence of seizures during the first week after status epilepticus, suggesting the lack of a latent period in this model. Our own recent observations suggest that the electrographic status epilepticus after pilocarpine treatment is far more intense than with the repeated, low-dose kainate model (Dudek et al., 2002, 2005), and the pilocarpine model may be more pron
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