Is the intestinal mucosa barrier malfunction involved in non-alcoholic steatohepatitis?
The pathogenesis of NASH remains unclear. Nowadays, lipid metabolism abnormality, insulin resistance and oxidative stress and lipid peroxidation reaction are thought to place an important role in the pathogenesis of NASH. Several researches have also demonstrated that the change of intestinal environment may play a role in NASH, which may be a cause of enterogenous endotoxemia. While the relationship between intestinal mucosa barrier function and NASH is uncertain. A research article to be published on 28 May 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Wan-Chun Wu from Yijishan Hospital established an NASH animal model by fat-rich diet to explore the change of intestinal mucosa barrier function in the progress of NASH. Several researches have demonstrated that the change of intestinal environment may play a role in NASH, which may be a cause of enterogenous endotoxemia. While the relationship between intestinal mucosa barrier function
