Is the Inflammatory Response Necessary?
Inflammation exists to protect and defend wounds against bacterial invasion. In the real world, wounds can become contaminated. However, in the laboratory setting, most wound models are sterile. Thus, to address this question, we will need more natural wound models. We would never suggest in the clinic to deplete all the inflammatory cells. One thing upon which we can all agree is that chronic inflammation is not going to help. Persistent inflammation kills. We could apply antibiotic to kill all the bacteria in a child in the hospital but how can we apply this to a chronic wound. An essential point is the underlying disease. Young and/or healthy people do not get chronic wounds. Chronic wounds occur with underlying disease. What about some chronic wounds that do not exhibit acute inflammation or blood vessels? Should we infect our laboratory models to make them more realistic?Timing is essential. Evolutionarily, tissues need a fast inflammatory response to survive, but this response ne
