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Is the induction of neuroblastoma differentiation by CCA mediated by its effects on the electrochemical gradient?

April 26, 2017CCA differentiation electrochemical gradient induction MEDIATED neuroblastoma

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Is the induction of neuroblastoma differentiation by CCA mediated by its effects on the electrochemical gradient?

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Various mitochondrial inhibitors are tested in neuroblastoma cells. Their effects on the mit-proteins and some cytoskeletal proteins are compared to those of CCA, a differentiation inducer. This comparison favours the hypothesis that the primary effect of CCA induction is an alteration of the electrochemical gradient.