Is the EndoPAT™ correlated to coronary endothelial function?
EndoPAT™ provides high degrees of sensitivity and specificity when compared to the assessment of coronary artery endothelial function. Coronary endothelial function is quantified by measuring arterial diameter change and blood flow in response to graded intra-coronary infusion of Acetylcholine during angiography. In a study performed by Bonetti et al (9) at the Mayo Clinic, Rochester, a group of 94 subjects underwent angiographic assessment of coronary endothelial function and subsequent EndoPAT™ tests. The results of this comparative study served as the basis for the FDA clearance of the EndoPAT™ in the detection of coronary endothelial dysfunction. An EndoPAT™ index cutoff value of 1.67 provides a sensitivity of 82% and a specificity of 77% and AUC 0.82 to diagnosing coronary endothelial function. (9) Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr., Kuvin JT, Lerman A. Noninvasive Identification of Patients with Early Coronary Atherosclerosis by Assessment of Digital Reactive Hyperem
