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Is the efficacy of Advocate affected by water?

advocate affected water
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Is the efficacy of Advocate affected by water?

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Exposure to water, as may occur with swimming or rainfall, beginning as soon as 60 minutes after treatment does not reduce the effectiveness of Advocate in the prevention of heartworm disease. Previous studies with advantage have shown that swimming or bathing with a mild grooming shampoo does not significantly reduce the effectiveness of imidacloprid against fleas.

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