Is the Draize Rabbit Eye Test Compatible with Eye Irritation Thresholds in Humans?
Draize rabbit eye test scores, as modified maximum average score, MMAS, for 68 pure bulk liquids were adjusted by the liquid saturated vapor pressure P°. These 68 adjusted scores, as log (MMAS/P°), were shown to be completely equivalent to eye irritation thresholds, EIT expressed as log (1/EIT), for 23 compounds in humans. Thus for the first time the Draize eye test in rabbits for pure bulk liquids is shown to be perfectly compatible with eye irritation thresholds in humans. The total data set for 91 compounds was analyzed by the general solvation equation of Abraham. Values of log (MMAS/P°) or log (1/EIT) could be fitted to a five-parameter equation with R2 = 0.936, SD = 0.433, AD = 0.000, and AAD = 0.340 over a range of 9.6 log units. When divided into a training set of 45 compounds, the corresponding equation could be used to predict the remaining 46 compounds in a test set with AD = -0.037 and AAD = 0.345 log units. Thus the 91 compound equation can now be used to predict further E
