Is the dose to inhibit the COX-2 enzyme in nude mice also adequate in human endometrial tissues?
Sachiko Matsuzaki and Michel Canis Department of Gynecology, Hôtel-Dieu,Polyclinique, CHU, Clermont-Ferrand, b.p. 69, 13 bd, L. Mafreyt, 63058, Clermont-Ferrand, France Email: smatsuzaki{at}chu-clermontferrand.fr’ + u + ‘@’ + d + ”//–> Sir, We read with great interest the paper by Hull et al. (2005). The authors examined whether nimesulide, a COX-2 inhibitor, reduced the size and number of ectopic human endometrial lesions in a nude mouse model of endometriosis. The authors commented that the dose of nimesulide administered to the nude mice was adequate to inhibit the COX-2 enzyme in vivo. However, we would like to question whether the dose administered to the nude mice was adequate to inhibit the COX-2 enzyme in human endometrial tissues. The authors collected endometrial tissues from patients with endometriosis during the secretory phase and injected them into nude mice. Endometrial tissues from patients with endometriosis have higher levels of COX-2 protein than those of women wit
