Is the combined oral contraceptive pill (OCP) contraindicated in women with a history of gallbladder disease?
No. The oral contraceptive increases secretion of cholic acid in bile, potentially leading to greater risk of gallstone formation, however the overall risk is small, rising to only 1.5-fold after five years of combined OCP use. This means that the incidence of clinical gall bladder disease among long-term users might rise from two to three cases per 1,000 women per year of use. Decisions about using the combined OCP should be based on individualized assessment of risks and benefits.
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