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Is the citrus aurantium (bitter orange) in SHAPE UP REDUCE harmful?

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Is the citrus aurantium (bitter orange) in SHAPE UP REDUCE harmful?

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No. The natural p-isonomer was used in SHAPE UP. Studies including one from the University of Connecticut, published in Pharmacotherapy (25, 12:1719-24, 2005) suggests that standardized p-synephrine from citrus aurantium does not alter blood pressure or heart rate in healthy volunteers.

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