Is the Children’s Brain Tumor Tissue Consortium (CBTTC) just another brain tumor tissue bank?
No, in fact the CBTTC is not actually a tissue bank. A tissue bank is a place that collects and holds brain tumor tissue collected at the time of surgery. This is called a deposit. Usually, the tumor is stored in a freezer until a researcher requests a piece of it. This is called a withdrawal. At that time some or all of the tissue is sent. Once it is sent, the researcher often uses it up so that no other different studies can be done. Tissue banks are generally “passive” structures that do not stimulate new research, often have poor quality control, and lack a comprehensive clinical database. The CBTTC is a unique research platform in which tumor tissue is processed for comprehensive molecular (e.g., DNA, RNA, and protein) analysis using state-of-the-art methods and the data results of that analysis, together with new brain tumor models and relevant clinical information, are sent back to the participating institutions. In comparison to tissue banks, the CBTTC actively stimulates resea
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