Is survivin a valuable prognostic index in pulmonary hypertension?
In several tumor series, presence of survivin correlated with a lower apoptotic index in vivo and shorter overall patient survival (15, 16). Whether these characteristics apply to iPAH is of great interest. There is considerable dissimilarity among patients with PAH regarding disease progression rates and treatment responses. Whether the level of survivin expression in pulmonary vessels reflects the potential for disease progression remains to be tested.
