Is stop codon K3326X variant associated with the disease?
1,2,3Mohammad Reza Akbari, 1Reza Malekzadeh, 1Dariush Nasrollahzadeh, 1Dayan Amanian, 2Inuk Zandvakili, 1Ramin Shakeri, 1Masoud Sotoudeh, 4Paolo Boffeta, 5Sanford M Dawsey, 6Parviz Ghadirian, 2Steven A Narod 1Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran, 2Women’s College Research Institute, University of Toronto, Toronto, Canada, 3Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada, 4International Agency for Research on Cancer, Lyon, France, 5Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, United States of America, 6Department of Nutrition, University of Montreal, Montreal, Canada In spite of the remarkable progresses in genetic oncology during past years, our knowledge about the genetic basis of esophageal cancer is limited. The high incidence of esophageal cancer among the Turkmen population in the southeastern Caspian littoral has made them ideal for genetic study of es