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No. It is minimally invasive. We routinely do skin biopsy on 1 side at 3 sites, above ankle (distal leg), above knee (distal thigh), and below hip (proximal thigh) using a 3 mm (diameter) biopsy punch. Since the biopsy size is so small, no stitches are needed. The biopsy sites will be healed within 1 week, but will leave small scars.
