Is respiratory modulation of ABP a useful indicator of vascular volume and cardiac filling pressure?
A number of publications have noted that the modulation of pulse pressure (SBP-DBP) by the respiratory cycle (especially in ventilated patients) is related to the level of the central venous pressure. Low CVP levels correlate with increased amplitude modulation of PP, and hypotensive patients showing this seem to respond better to volume replacement than patients with less modulation amplitude. In determining the etiology of hypotensive episodes it is important to assess vascular volume in a non-invasive manner. We would like to explore the effectivenesss of respiratory modulation of PP in our large MIMIC database [CCM 2009, 37:2570-2575, and editorial on p. 2662]. One challenge is that some blood pressure waveforms in the database are sampled with a low amplitude resolution (only 8 bits) which leads to heavy quantization and poor estimation of the cyclic variation in the pulse pressure. It is therefore necessary to restore the original pulse waveform in order to preserve features such
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