Is post-fusion vesicle behaviour controlled by physiological stimulation?
The above discussed work shows that in principle vesicle dynamics can affect vesicle content release but there is only limited evidence for its regulation in a physiological context. In a comprehensive study Fulop et al.44 investigated the physiological control of secretion in chromaffin cells. At low, tonic stimulation chromaffin cells secrete background levels of catecholamines but during activation of sympathetic drive the cells not only increase catecholamine secretion but also secrete peptides. It is known that both catecholamines and peptide co-exist in the same secretory vesicles and Fulop et al. present evidence that it is agonist dependent regulation of fusion pore dilation, during high levels of cell stimulation that enables secretion of the larger peptides.44 In another example, in lactotrophs it has been shown that transient fusion dominates the secretory activity in unstimulated cells (so-called spontaneous activity) but that when the cells are stimulated with high potassi
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