Is Oxidative Stress the Unifying Element?
From the Departments of Obstetrics and Gynecology/Physiology, University of Alberta; and the Women and Children s Health Research Institute, Edmonton, Alberta, Canada. Correspondence to Sandra T. Davidge, 220 HMRC, University of Alberta, Edmonton, Alberta, Canada T6G 2S2. E-mail sandra.davidge{at}ualberta.ca’ + u + ‘@’ + d + ”//–> In this issue of Hypertension, Yzydorczyk et a11 present a novel approach to investigate how adverse environmental conditions during the early stages of life can lead to cardiovascular complications during adulthood. The authors used a model in which newborn rats were exposed to 80% oxygen from postnatal days 3 to 10. Although the rats used in the study were born at term, the authors suggest that, in some respects, their developmental stage is equivalent to that of a preterm fetus, allowing some aspects, such as kidney, lung, and vascular development, to be related to premature infants. Therefore, the approach taken by Yzydorczyk et al1 also provides additi
