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Is ondansetron more effective than granisetron for chemotherapy-induced nausea and vomiting?

April 26, 2017chemotherapy-induced effective granisetron nausea ondansetron vomiting

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Is ondansetron more effective than granisetron for chemotherapy-induced nausea and vomiting?

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Author(s): Steele SK, Vrabel M Affiliation(s): Information resources supervisor, Oncology Nursing Society, Pittsburgh PA. Publication date & source: 2007-12, Clin J Oncol Nurs., 11(6):809-13. Publication type: Nausea and vomiting are two of the most distressing side effects of chemotherapy. Guidelines recommend the use of 5-HT3 receptor antagonists as a pharmacologic intervention for acute and delayed nausea and vomiting for moderately and highly emetogenic chemotherapy. Although newer antiemetics and 5-HT3 receptor antagonists are available, ondansetron and granisetron still are used widely. A review of the literature was conducted to identify trials that compared the antiemetic efficacy of ondansetron and granisetron. Studies were identified by searching the PubMed(R), EMBASEtrade mark, Ovid MEDLINE(R), CINAHL(R), and Evidence-Based Medicine Reviews databases. The six studies reviewed in this article were either a meta-analysis; a randomized, controlled trial; or another type of rese