Is OB glue paste technique ideal to establish nude mouse transplantation model?
Establishment of human gastric cancer nude mouse transplantation models has undergone three representative stages: subcutaneous transplantation of cell suspension, gastric wall seeding of cell suspension, and intra-gastric wall transplantation of histologically intact tissue, of which the fresh tissue orthotopic transplantation model has two types: the “suture method”and the “gastric bursa method”.But the “suture method”or the “gastric bursa method” transplantation has many practical difficulties and disadvantages in establishing the model; for example, the tumor tissue is easy to fall off postoperatively; manipulation is complex and needs relatively high skills; there may be great blood loss during suturing, and mortality is relatively high. A research article to be published on August 14, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Xu from Shanghai Changzheng Hospital. The present study used OB glue paste technique to establis
