Is NiTi biocompatible and can it be used as an implant material?
NiTi is generally a safe implant material as the FDA has approved many devices for long-term implant applications. A large amount of data is available in various publications. A very good comprehensive study may be found under http://herkules.oulu.fi/isbn9514252217/ According to an in-vitro study of passivated NiTi in Hank’s solution, the Ni release rate was the highest of 14.5 x 10-7 mg/cm-2sec-1 in the first day but decreased quickly to an undetectable level in 10 days. In-vivo studies of NiTi implants in soft tissues indicated that the overall inflammatory response to NiTi was very similar to that of stainless steels and Ti-6V-4Al alloy. Studies on NiTi vascular stents showed a mild inflammatory response, minor atrophy of vessel media, acceptable fibrocellular tissue growth and endotheliazation, indicating that the biocompatibility of NiTi stents is equal to or better than that of stainless steel stents. A comparative in-vivo study of NiTi and stainless steel intramedullary rods on
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